ParkinsonCanadaV1, Main, Exploration, bibRecord, 000B92

Movement disorders 2:Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Identifieur interne : 000B92 ( Main/Exploration ); précédent : 000B91; suivant : 000B93

Movement disorders 2:Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Auteurs : A. Jon Stoessl [Canada] ; Stephane Lehericy [France] ; Antonio P. Strafella [Canada]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2014.

RBID : Pascal:14-0205180

Descripteurs français

Pascal (Inist)
- Imagerie médicale, Connaissance, Noyau gris central, Maladie de Parkinson, Médecine, Dystonie, Intuition.
Wicri :
- topic : Médecine.

English descriptors

KwdEn :
- Basal ganglion, Dystonia, Knowledge, Medical imagery, Medicine, Parkinson disease.

Abstract

Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging is the best way to detect and monitor dopamine deficiency, and will probably continue to be the best biomarker for assessment of the effects of disease-modifying therapies. However, advances in magnetic resonance enable the separation of patients with Parkinson's disease from healthy controls, and show great promise for differentiation between Parkinson's disease and other akinetic-rigid syndromes. Radionuclide imaging is useful to show the dopaminergic basis for both motor and behavioural complications of Parkinson's disease and its treatment, and alterations in non-dopaminergic systems. Both PET and MRI can be used to study patterns of functional connectivity in the brain, which is disrupted in Parkinson's disease and in association with its complications, and in other basal-ganglia disorders such as dystonia, in which an anatomical substrate is not otherwise apparent. Functional imaging is increasingly used to assess underlying pathological processes such as neuroinflammation and abnormal protein deposition. This imaging is another promising approach to assess the effects of treatments designed to slow disease progression.

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Corpus: 000048
to stream PascalFrancis, to step Curation: 000C04
to stream PascalFrancis, to step Checkpoint: 000012
to stream Main, to step Merge: 000B97
to stream Main, to step Curation: 000B92

Le document en format XML

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<front><div type="abstract" xml:lang="en">Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging is the best way to detect and monitor dopamine deficiency, and will probably continue to be the best biomarker for assessment of the effects of disease-modifying therapies. However, advances in magnetic resonance enable the separation of patients with Parkinson's disease from healthy controls, and show great promise for differentiation between Parkinson's disease and other akinetic-rigid syndromes. Radionuclide imaging is useful to show the dopaminergic basis for both motor and behavioural complications of Parkinson's disease and its treatment, and alterations in non-dopaminergic systems. Both PET and MRI can be used to study patterns of functional connectivity in the brain, which is disrupted in Parkinson's disease and in association with its complications, and in other basal-ganglia disorders such as dystonia, in which an anatomical substrate is not otherwise apparent. Functional imaging is increasingly used to assess underlying pathological processes such as neuroinflammation and abnormal protein deposition. This imaging is another promising approach to assess the effects of treatments designed to slow disease progression.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Movement disorders 2:Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Movement disorders 2:Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri